The late Sunday window gets a little NFC West flavor when the Los Angeles Rams head to Arizona for a 4:05 PM ET kickoff. This one starts with star power through the air. Matthew Stafford has piled up 2,374 passing yards and 16 touchdowns this season, and Puka Nacua keeps stretching defenses with 715 receiving yards. Arizona has answers to find, quickly.
The Rams offense arrives with balance, too. Kyren Williams has added 593 rushing yards and six touchdowns, giving Los Angeles more than one way to control tempo. Stafford’s experience still drives the conversation, though. When the Rams offense gets into rhythm, the field starts looking very small for opposing secondaries. Nacua’s production jumps off the page, and Arizona’s defense gets a full afternoon of dealing with it.
The Cardinals counter with Jacoby Brissett, who has thrown for 1,719 yards and 10 touchdowns this season. Arizona’s offense has leaned on Trey McBride as its top receiving option, and the tight end enters this matchup with 598 receiving yards and five touchdowns. Tyler Allgeier has added 369 rushing yards and two scores on the ground. Arizona does not lack for opportunities here, but the offense needs cleaner drives against a Rams team entering as a clear favorite.
DraftKings lists Los Angeles as a 9.5-point road favorite with a total set at 40.5. The moneyline sits at Rams -455 and Cardinals +350. That spread tells the story of the matchup entering Sunday: Los Angeles is expected to dictate the game, while Arizona needs to create disruption early and keep possessions from snowballing.
There is also the divisional angle hanging over this game. Familiar opponents usually bring tighter possessions and fewer surprises, but Stafford and the Rams offense have enough proven production to change games quickly. Arizona’s best path likely runs through extending drives and keeping McBride involved in the middle of the field. If Brissett gets comfortable early, the crowd suddenly has a reason to stay loud deep into the fourth quarter.
Looking ahead, this feels like one of those games that can swing momentum in a hurry. The Rams have the bigger statistical profiles across the board, especially at quarterback and receiver. Arizona gets the benefit of home field and a chance to punch back inside the division. Late afternoon window, NFC West stakes, and an offense led by Stafford walking into the desert with confidence. That is enough to keep attention locked in Sunday.

